It gradually becomes a source of pain and the condition often leads to disfiguration. Media Gallery Swelling of the gingival mucosa around the right lower canine and multiple areas of erythema, erosions, and bleeding throughout the upper gingival mucosa.
Of this large group of drugs, the dihydropyridines are the agents most frequently implicated. J Ir Dent Assoc. Upregulation of heme oxygenase-1 expression in gingiva after cyclosporin A treatment. Drugs associated with gingival enlargement can be broadly divided into three categories: Amlodipine was substituted with Losartan potassium and chlorothiazide combination 50 mg, The enlarged gingiva was Erythematous, soft and edematous, and showed a lobulated surface with absence of stippling.
Gingival enlargement, along with its cosmetic implications, also provides a niche for growth of microorganisms and is a serious concern for both the patient and clinician. The effects of antiepileptic drugs on oral health. Current studies on the pathogenetic mechanism of drug associated enlargement are focusing on the direct and indirect effects of these drugs on gingival fibroblast metabolism.
J Can Dent Assoc. The patient was recalled after 1 week for suture Management of amlodipine influenced gingival overgrowth. Abstract Gingival enlargement is one of the side effects Management of amlodipine influenced gingival overgrowth with certain drugs.
To date there has been no clear cut literature which could consolidate the pathogenesis, clinical manifestations, and the management of affected patients. Gingival enlargement is a well-known consequence of administration of some anticonvulsants, the immunosuppressant drug cyclosporine A CsAand calcium channel blockers, and it may create speech, mastication, tooth eruption, and esthetic problems.
It is a serious concern for both the patient and the clinician due to its unesthetic appearance and formation of new niches for periodontopathogenic bacteria. Prevalence Amlodipine-induced gingival enlargement is comparatively less prevalent than other calcium channel blocker.
An increasing number of medications are associated with gingival enlargement. Low level laser therapy LLLT as adjuvant in the management of drug induced gingival hyperplasia: Although pharmacologic effect of each of these drugs is different and directed toward various primary target tissues, all of them seem to act similarly on secondary target tissue, i.
Efficacy of azithromycin in the treatment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. Thus, increased fibroblastic proliferation and collagen synthesis occurs. Effectiveness of periodontal treatments on cyclosporine induced gingival overgrowth in transplant patients.
The enlargement was more on the left side because of unilateral mastication from right side. Series of three cases. Amlodipine-induced gingival enlargement was diagnosed and managed by thorough scaling and root planning.
Furthermore, within the group of patients that develop this unwanted effect, there appears to be variability in the extent and severity of the gingival changes. There was generalized bleeding on probing.
Dose-dependent gingival overgrowth induced by cyclosporin in rats. Congenital gingival hyperplasia in a neonate with foetal valproate syndrome. Intraoral examination revealed poor oral hygiene, generalized nodular enlargement of gingiva mainly on the facial aspect of teeth.
Proliferative and inductive effects of Cyclosporine a on gingival fibroblast of child and adult. Find articles by Rashmi P. At the 3-month recall, the patient showed significant resolution of gingival inflammation on the buccal aspect Figure 4 and uneventful healing on the lingual aspect Figure 5.
Periodontal Examination revealed generalized moderately deep pocket. Prevention and Treatment of Gingival Enlargement Prevention In the susceptible patient, drug-associated gingival enlargement may be ameliorated, but not prevented by elimination of local factors, meticulous plaque control, and regular periodontal maintenance therapy.
It seems likely that the use of medications for treatment of medical conditions and the potential to cause gingival overgrowth will increase in the years to come.
A provisional diagnosis of drug-induced gingival enlargement was made for the patient.
Intraoral examination revealed slight improvement in the condition of gingiva. Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni.
Histologically, the lesion was diagnosed as fibroepithelial hyperplasia, and was indicative of amlodipine-induced gingival hyperplasia based on clinical and histological evidence.
Amlodipine-induced gingival enlargement is comparatively less prevalent among calcium channel blockers.odontal management and maintenance.
Case Report: Gingival overgrowth influenced by Amlodipine usually begins at the interdental papilla, which occurs within 6 months of taking medications at a dose of 10mg/day.
Few cases have reported at a dose of 5 mg of Amlodipine when. Amlodipine-Induced Gingival Overgrowth: A Case Report Yogesh Upadhyay This case report describes the management of gingival overgrowth in a hypertensive patient taking amlodipine.
Combination of surgical gingivectomy and (Hallmon and Rossman, ).
The treatment may consist of. Dec 09, · Debate is ongoing regarding whether drug-induced gingival overgrowth is due to hyperplasia of the gingival epithelium or of submucosal connective tissue, and/or both. Srivastava AK, Kundu D, Bandyopadhyay P, Pal AK. Management of amlodipine-induced gingival enlargement: Series of three cases.
J Indian Soc Periodontol. Oct. Amlodipine induced gingival overgrowth: A case report Amlodipine, Gingival enlargement, management of DIGO includes the scalpel gingivectomy.
Jul 15, · Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.
This case series presents diagnosis and management of amlodipine-induced gingival. The prevalence with amlodipine, %, is much lower. 3 Seymour et al 4 were the first to report on amlodipine-induced gingival overgrowth, and there have been only few reported associations of gingival overgrowth with this drug.Download